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for genome-scale analysis of protein functions and evolution. Nucleic Acids Res 2000, 28(1):33–36.PubMedCentralPubMedCrossRef 57. Morris JA, Gardner MJ: Calculating confidence intervals for relative risks (odd ratios) and standardised ratios and rates. Br Med J 1988, 296(6632):1313–1316.CrossRef Competing interests CDC has a financial interest (stock ownership) in Renmatix, Inc. Renmatix is developing technology to produce sugars from biomass via abiotic processes. He acquired stock by exercising options awarded to him as compensation for providing technical advice in the early history second of the company. He no longer has any relationship with the company other than stock ownership. It is unlikely that he would be able to affect the future value of the stock through this publication, even if he were motivated to do so.
CDC is the Director of the Institute for a Secure and Sustainable Environment which provided funding to support JLL through institutional funds that he has been entrusted to administer. This does not alter our adherence to all the BMC Microbiology policies on sharing data and materials. Authors’ contributions JLL conceived of the study, participated in the design of experiments, performed all experiments, analyzed and interpreted data. MR conceived of the study, participated in the design of experiments and contributed to the fermentation experiments. SDB conceived of the study, participated in the design of experiments, contributed to the analysis and interpretation of the data. JRM conceived of the study, participated in the design of experiments, contributed to the analysis and interpretation of the data.