Chris Lockwood, Dr. Kevin XAV-939 Yarasheski, Joe Company, Jacob Brown, Leigh Gilpin and Dr. Robert Backus for their intellectual insight during

the completion of experiments.”
“Background Studies suggest that playing professional football can impact the health of the athlete and concerns are raised that they may experience negative health consequences that may affect their quality of life when they retire. The purpose of this exploratory investigation is to determine the effects of dietary supplementation on the quality of life of retired football players. Methods Questionnaires were completed by 15 ambulatory Selleckchem Kinase Inhibitor Library retired football players with the average age of 49.6 (±8.2) years and average professional football career of 7.6 (±3.2) years. In this open label study, the subjects had daily intake of the following supplements for 6 months: Fish oil with vitamin D3, antioxidant, natural vitamin and mineral supplement, glyconutrient

and a phytosterol-amino acid complex. Outcome measures included “Healthy Days Measures” (CDC HRQOL-4), WHO Quality of Life (WHOQOL-BREF), Profile of Mood States (POMS) and Memory Functioning Questionnaire (MFQ). Self-assessments of pain of joints and extremities as well as range of motion were also collected using a questionnaire. selleck kinase inhibitor Mean differences were assessed between baseline and each data collection point at 1, 3 and 6 months. Results Statistically significant differences from baseline were obtained in key outcome measures. CDC HRQOL general health rating showed improvement at month 1 (p=0.008) and sustained to month 6 (p<0.0001). There was increased number of healthy days per month related to physical health and mental health and the improvement in the number of mental health days was significant at 6 months (p=0.029). WHOQOL-BREF showed improvement on the rating of quality of life at 6 months old (p=0.038) and satisfaction with health in all measurement

points (p<0.05). Both the Physical and Psychological Domains showed significant improvement at 6 months (p<0.05). General Rating of Memory using the MFQ showed significant improvement at 3 and 6 months (p<0.05). The POMS showed that the participants rated the Vigor scale significantly higher at 3 months compared to the baseline (p=0.024). Self-assessment of pain showed decreasing trends but only the elbow and knee pain showed statistically significant improvement at 1 and 3 months, (p<0.05). There were no adverse events related to the supplementation. Conclusions This preliminary study demonstrates that multiple dietary supplementations enhanced the quality of life of this special group of retired football players. However, a larger well controlled clinical trial is needed to determine whether these findings can be replicated not only in this special population but also in other group of retired athletes.