2 mu g/L. Maternal fish intake during pregnancy, mother’s age, country of origin, educational level, employment status and parity, as well as area of study and season of delivery, were associated with cord blood T-Hg levels. A doubling in consumption of large oily fish was associated with an increase of 11.4% (95% CI: 3.8 to 19.6%) in cord blood T-Hg levels, followed by an increase of 8.4% (95% CI: 5.7 to 11.2%) in the case of canned tuna and 8.3% (95% CI: 5.5 to 11.1%) in that of lean fish.
Conclusion: A high
proportion of newborns had elevated Sapitinib concentrations of cord blood T-Hg according to the current US-EPA reference dose (5.8 mu g/L for methylmercury). Mercury concentrations were related to maternal fish consumption, with large oily fish being the main contributor. (C) 2010 Elsevier Ltd. All rights reserved.”
“Mechanisms underlying Down syndrome (DS)-related mental retardation (MR) remain poorly understood. In trisomic offspring, non-disjunction may result in the reduction to homozygosity of a susceptibility allele inherited from a heterozygous parent. Accordingly, we sought evidence for allelic non-disjunction in the GluK1 Nepicastat clinical trial gene that encodes the critical kainite-binding glutamate receptor subunit-5, maps to chromosome 21q22.1 in the DS critical region and is expressed in brain regions responsible for learning
and memory. Three polymorphisms of GluK1 [522(A/C) rs363538; 1173(C/T) rs363430 and 2705(T/C) rs363504] were genotyped in 86 DS patient families by means of PCR-coupled RFLP assays and evaluated with respect to allele frequency, heterozygosity, linkage disequilibrium, stage and parental origin of allelic non-disjunction.
We report that the distribution of allele frequencies is in Hardy-Weinberg equilibrium. Moderate heterozygosity (0.339) and a major allele frequency of 0.78 render the 1173(C/T) marker informative. Pair-wise comparisons reveal that 522(A/C)-1173(C/T) [chi(2) = 31.2, df = 1, p = 0.0001; D' = 0.42] and 1173(C/T)-2705(T/C) [chi(2) = 18.3, df = 1, p = 0.0001; D' = 0.34] are in significant PU-H71 nmr linkage disequilibrium of weak magnitude. The estimated ratio of meiosis-I to meiosis-II errors arising from allelic non-disjunction of 1173(C/T) is 4: 1 in maternal cases and 2: 1 in paternal cases. Studies including additional markers and patient samples are warranted to further substantiate present findings.”
“Some cases of specific cutaneous manifestations of acute myelogenous leukemia (AML) may mimic inflammatory dermatoses both clinically and histopathologically, presenting with an inconspicuous maculopapular eruption and with only sparse dermal infiltrates. The authors studied the histopathological and immunohistochemical features of 17 biopsies from 16 patients (11 men and 5 women, age range 15-85 years) presenting with minimal skin infiltrates as the first manifestation of AML or as first sign of recurrence after complete remission of the disease.