5 47 36 Indian 30 9 30 43 19 Mixed ancestry 213 44 21 26 15 Black 1600 310 19 25 14 Total 2031 441 22 27.5 16.3 More boys than girls sustained CHIR-99021 supplier fractures (27.5% vs. 16.3%; p < 0.001) throughout all age groups except in the first year of life. (Figure 2) Of all fractures, 64% occurred in males. The peak age of fractures was between 11–14.9 years for the sexes

combined. The peak fracture rate for girls was between 11–13.9 years of age during which period 10% fractured and between 11–14.9 years of age for boys when 19% fractured. The fracture rate from 11–14.9 years of age in white males was almost three times higher than in black males (101.1 [95% CI 59.9–142.4] vs. 37.3 [95% CI 19.5–55.2] /1000 children/annum, p < 0.001) and double that of the mixed ancestry group (49.5 [95% CI 10–89] /1000 children/annum, p < 0.002). The fracture rate from 11–13.9 years of age in white females was three times greater than in black (60.6 [95% CI 17.1–104.1] vs. 17 [95% CI 9–25.1] /1000 children/annum; p < 0.001) and mixed ancestry females (18.7 [95% CI -4.6–41.9] /1000 children/annum; p < 0.003). Fig. 2 Fractures

per year by age and sex distribution. The number of males and females in the study were similar Of the 441 children reporting fractures, HSP90 80% sustained a single fracture and 20% fractured on more than selleck one occasion. More boys than girls sustained two or more fractures (23% vs. 15% of those fracturing; p < 0.001). The maximum number of fractures sustained by an individual was five. The most common site of fracture for both sexes across the ethnic groups was the upper limb (57%) (Fig. 3). Other fracture sites included the neck, ribs, pelvis, face, vertebrae and skull. The fracture rate at each site was highest

in white children (p < 0.025) (Fig. 3). Fracture rates at the different sites were similar in the black and mixed ancestry groups, but lower than in white children. Fig. 3 Fracture rates over 15 years between ethnic groups at the different fracture sites. The p values indicate the significant difference between fracture rates of the white children and those of the black and mixed ancestry children Most fractures occurred as a consequence of grade 2 trauma within all ethnic groups. There was a statistically significant difference in the grades of trauma causing fractures between the white and black ethnic groups (p < 0.025), with whites generally Vistusertib concentration fracturing at more severe levels of trauma. (Table 3).