6 years, range: 34-54 years; CAG repeats, range: 19-29). Testosterone correlated inversely with participant age (r = -0.392 p = 0.012) and positively with number of CAG repeats (r = 0.45, p = 0.003). In partial correlations adjusted for testosterone level, reactivity in the ventral amygdala was lowest among men with largest number of CAG repeats. This inverse association was seen in both the right Navitoclax chemical structure (r(p) = -0.34, p < 0.05)
and left (r(p) = -0.32, p < 0.05) hemisphere. Activation of dorsal amygdala, correlated positively with individual differences in salivary testosterone, also in right (r = 0.40, p < 0.02) and left (r = 0.32, p < 0.05) hemisphere, but was not affected by number of CAG repeats. Hence, androgenic influences on threat-related reactivity in the ventral amygdala may be moderated partially by CAG length variation in the AR gene. Because individual differences in salivary testosterone also predicted dorsal amygdala reactivity and did so independently of CAG repeats, it is suggested that androgenic influences within this anatomically distinct region may be mediated, in part, by non-genomic or AR-independent mechanisms. (c) 2009 Elsevier Ltd. All rights reserved.”
“Background The intensity of chemotherapy and need for additional
radiotherapy in patients with advanced stage Hodgkin’s lymphoma has been unclear. We did a prospective randomised clinical trial comparing two reduced-intensity chemotherapy variants with our previous standard regimen. Chemotherapy was MLN0128 followed by PET-guided radiotherapy.
Methods In this parallel group, open-label, multicentre, 10058-F4 non-inferiority trial (HD15), 2182 patients with newly diagnosed advanced stage Hodgkin’s lymphoma aged 18-60 years were randomly assigned to receive either eight cycles of BEACOPP(escalated) (8xB(esc) group), six cycles of BEACOPP(escalated) (6xB(esc) group), or eight cycles of BEACOPP(14) (8xB(14) group). Randomisation (1:1:1) was done centrally by stratified minimisation. Non-inferiority of the primary endpoint, freedom from treatment failure,
was assessed using repeated CIs for the hazard ratio (HR) according to the intention-to-treat principle. Patients with a persistent mass after chemotherapy measuring 2.5 cm or larger and positive on PET scan received additional radiotherapy with 30 Gy; the negative predictive value for tumour recurrence of PET at 12 months was an independent endpoint. This trial is registered with Current Controlled Trials, number ISRCTN32443041.
Findings Of the 2182 patients enrolled in the study, 2126 patients were included in the intention-to-treat analysis set, 705 in the 8xB(esc) group, 711 in the 6xB(esc) group, and 710 in the 8xB(14) group. Freedom from treatment failure was sequentially non-inferior for the 6xB(esc) and 8xB(14) groups as compared with 8xB(esc).