8 ± 9.6% at the time of their inclusion in the extension study (at year 6). Fig. 2 Cumulative incidence of new vertebral fracture (A), new nonvertebral fracture (B), and new osteoporotic fracture

(C) in the 10-year population between 0 LDN-193189 and 5 years’ treatment with strontium ranelate and between 6 and 10 years’ treatment with strontium ranelate (gray bars) and in the FRAX®-matched placebo group of TROPOS between 0 and 5 years (white bars) The effect of strontium ranelate on fracture incidence was evaluated by comparison with a FRAX®-matched placebo group identified in the TROPOS placebo arm. The FRAX®-matched placebo population of TROPOS had a mean FRAX® 10-year probability of major osteoporotic fracture of 25.8 ± 9.3% at the baseline (year 0). The patients in these two populations were Ilomastat ic50 similar in terms of age, BMI, time since menopause, parental history of osteoporotic fracture, and prevalence of osteoporotic fracture

(Table 2). The cumulative incidences of fracture in PD173074 the 10-year population were compared with the cumulative incidence of fracture in the FRAX®-matched placebo population (Fig. 2). The cumulative incidence of new vertebral fractures in the 10-year population in years 6 to 10 was significantly lower than that observed over 5 years in the FRAX®-matched placebo population (20.6 ± 3.0% versus 28.2 ± 2.4%, respectively; relative reduction in risk [RRR] 35%, P = 0.016). Similarly, the 10-year population had significantly lower rates of nonvertebral fracture and new osteoporotic fracture in

years 6 to 10 than the FRAX®-matched placebo population over 5 years (nonvertebral fracture: 13.7 ± 2.3% versus 20.2 ± 2.2%, respectively, RRR 38%, P = 0.023; new osteoporotic fracture: 30.3 ± 3.1% versus 39.2 ± 2.5%, RRR 30%, P = 0.012). Table 2 Main characteristics of the FRAX®-matched groups at year 0, in comparison with Sorafenib supplier the characteristics of the 10-year population at 5 years   10-Year population at 5 years (n = 233) TROPOS FRAX®-matched placebo group at year 0 (n = 458) FRAX score (%) 25.8 ± 9.6 25.8 ± 9.3 Age (years) 77.3 ± 5.3 76.3 ± 4.7 Body mass index (kg/m2) 25.8 ± 4.1 25.2 ± 3.7 Time since menopause (years) 28.4 ± 6.8 28.4 ± 7.4 Parental history of osteoporotic fracture, n (%) 92 (39) 146 (32) ≥ 1 Prevalent osteoporotic fracture, n (%) 177 (76) 309 (67) Bone mineral density Over the 10-year period, lumbar BMD increased continuously with a mean relative change from baseline of 34.5 ± 20.2% (Table 3) in the 10-year population treated with strontium ranelate. At this site, the annual change remained significant over the whole 10-year period (P < 0.001 up to year 9 and P = 0.002 for the last year). After 10 years’ treatment with strontium ranelate, the mean relative changes in BMD from baseline were 10.7 ± 12.1% at the femoral neck and 11.7 ± 13.6% for total hip. At both sites, the BMD increased significantly until year 7 and remained stable thereafter.