Nat Biotechnol 2007, 25:84–90.Alvocidib mw PubMedCrossRef 50. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, Yu Q: miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb–E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev 2009, 23:2388–2393.PubMedCrossRef
51. Alpini PCI-32765 ic50 G, Glaser SS, Zhang JP, Francis H, Han Y, Gong J, Stokes A, Francis T, Hughart N, Hubble L: Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer. J Hepatol 2011, 55:1339–1345.PubMedCrossRef 52. Saito Y, Friedman JM, Chihara Y, Egger G, Chuang JC, Liang G: Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun 2009, 379:726–731.PubMedCrossRef 53. Wotschofsky Z, Liep J, Meyer H-A, Jung M, Wagner I, Disch Baf-A1 chemical structure AC, Schaser KD, Melcher I, Kilic E, Busch J: Identification of metastamirs as metastasis-associated MicroRNAs in clear cell renal cell carcinomas. Int J Biol Sci 2012, 8:1363–1374.PubMedCrossRef
54. Lodygin D, Tarasov V, Epanchintsev A, Berking C, Knyazeva T, Körner H, Knyazev P, Diebold J, Hermeking H: Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 2008, 7:2591–2600.PubMedCrossRef 55. Lujambio A, Calin G, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga L, Rossi S, Nicoloso M, Faller W: A microRNA DNA methylation signature for human cancer metastasis. Proc Natl
Acad Sci U S A 2008, 105:13556–13561.PubMedCrossRef 56. Chang K, Chu T, Gong N, Chiang W, Yang C, Liu C, Wu C, Lin S: miR-370 modulates insulin receptor substrate-1 expression and inhibits the tumor phenotypes of oral carcinoma. Oral Dis 2013, 19:611–619.PubMedCrossRef 57. Chen Y, Gao W, Luo J, Tian R, Sun H, Zou S: Methyl-CpG binding protein MBD2 is implicated in methylation-mediated suppression of miR-373 in hilar cholangiocarcinoma. Oncol Rep 2011, 25:443.PubMed 58. Rauhala HE, Jalava SE, Isotalo J, Bracken H, Lehmusvaara S, Tammela TLJ, Oja H, Visakorpi T: miR‒193b is an epigenetically regulated putative acetylcholine tumor suppressor in prostate cancer. Int J Cancer 2010, 127:1363–1372.PubMedCrossRef 59. Formosa A, Lena A, Markert E, Cortelli S, Miano R, Mauriello A, Croce N, Vandesompele J, Mestdagh P, Finazzi-Agrò E: DNA methylation silences miR-132 in prostate cancer. Oncogene 2012, 32:127–134.PubMedCrossRef 60. Zaman M, Chen Y, Deng G, Shahryari V, Suh S, Saini S, Majid S, Liu J, Khatri G, Tanaka Y: The functional significance of microRNA-145 in prostate cancer. Br J Cancer 2010, 103:256–264.PubMedCrossRef 61. Dohi O, Yasui K, Gen Y, Takada H, Endo M, Tsuji K, Konishi C, Yamada N, Mitsuyoshi H, Yagi N: Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma. Int J Oncol 2013, 42:411–418.PubMed 62.