Rump A, Morikawa Y, Tanaka M, Minami S, Umesaki N, Takeuchi M, Mi

Rump A, Morikawa Y, Tanaka M, Minami S, Umesaki N, Takeuchi M, Miyajima A: Binding Ipatasertib nmr of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol

Chem 2004, 279:9190–9198.PubMedCrossRef 24. Chang CL, Wu TC, Hung CF: Control of human mesothelinexpressing tumors by DNA vaccines. Gene Ther 2007, 14:1189–1198.PubMedCrossRef 25. Huang CY, Cheng WF, Lee CN, Su YN, Chien SC, Tzeng YL, Hsieh CY, Chen CA: Serum mesothelin in epithelial ovarian carcinoma: a new screening marker and prognostic factor. Anticancer Res 2006, 26:4721–4728.PubMed 26. Baker SJ, Markowitz S, Fearton ER, WilIson JKU, Vogelstemn B: Suppression of human colorectal carcinoma cell growth by wild type p53. Science (Washington DC) 1990, 249:912–915.CrossRef 27. Mercer WE, Shields MT, Amin M, Sauve MGJ, Appella E, Romano JW, UlIrich SJ: Negative growth regulation this website in a glioblastoma cell line that conditionally expresses human wild-type p53. Proc NatI

Aced Sd USA 1990, 87:6166–6170.CrossRef 28. DilIer L, Kassel J, Nelson CE, Gryka MA, Litwak G, Gebhardt M, Bressac B, Ozturk M, Baker S, Vogelstemn B, Friend SH: p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol 1990, 10:5772–5781. 29. Chen PL, Chen Y, Bookstein R, Lee WH: Genetic mechanisms of tumor suppression by the human p53 gene. Science (Washington DC) 1990, 250:1576–1579.CrossRef 30. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B: PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001, 7:673–682.PubMedCrossRef 31. Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L: PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003, 100:1931–1936.PubMedCrossRef 32. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI: The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 2006, 443:214–217.PubMedCrossRef 33. Ming L, Cyclic nucleotide phosphodiesterase Sakaida T, Yue W, Jha A, Zhang L, Yu J: Sp1 and p73

activate PUMA following serum starvation. Carcinogenesis 2008, 29:1878–1884.PubMedCrossRef 34. Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, et al.: p73 Induces apoptosis via PUMA VX-680 cell line transactivation and Bax mitochondrial translocation. J Biol Chem 2004, 279:8076–8083.PubMedCrossRef 35. Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, Adams JM, et al.: Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 2005, 123:641–653.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions ZCN and TY carried out the design of the experiments, performed most of experiments and drafted the manuscript. JW and ZHL participated in establishing the nude models. SSC and JYS participated in the experiments of cell culture and molecular biology. ZCN participated in statistical analysis and interpretation. TY and SSC participated in the design of the experiments. All authors read and approved the final manuscript.

Comments are closed.