SF-treated HSC had significantly increased apoptosis rate compared with the untreated; after addition of GGPP, the
apoptosis rate decreased. SF reduced basal intrahepatic resistance and responsiveness of methoxamine on hepatic vascular smooth muscle. Conclusion: SF reduces fibrogenesis and decreases portal pressure of cirrhotic rats by down-regulating RhoA/Rho-kinase signaling pathway. Key Word(s): 1. sodium ferulate; 2. portal hypertension; 3. RhoA; 4. HSC; Presenting Author: SHAHRAM AGAH Corresponding Author: SHAHRAM AGAH Affiliations: colorectal Objective: About check details 10% of cirrhotic patients are unresponsive to sodium restriction and diuretics and develop refractory ascites. Such patients usually require recurrent large volume paracentesis and lots of hospital
admissions. Hereby, we introduce a method applying a central vein (CV) catheter for large volume paracentesis in patients with refractory ascites. Methods: Non-tunneled triple lumen central vein catheter was used to drainage the ascites fluid of 30 cirrhotic patients. After precise percussion the point of highest fluid accumulation was marked for puncture. Then, the skin and subcutaneous tissue were anesthetized. CV catheter set guide-wire was entered into the peritoneal cavity and the dilator of the CV catheter set was passed through the guide wire and extracted after some rotations around its insertion site on the skin. The catheter was passed over the guide wire; the guide wire was extracted gradually from one of the lumens and fixed to the skin. Results: Nineteen males and 11 females with mean age of 59.4 ± 11.7 year old underwent the procedure. A minimum of 9 and maximum of 29 liters (12 ± 6.6 L) click here ascites fluid drained during a minimum of 2 and maximum of 5 days of hospital stay. None of the patients develop hemodynamic instability. Number of rehospitalizations for paracentesis was 1.9 times during the following year. No complication occurred. medchemexpress Conclusion: This technique seems to be a simple noninvasive method that can be performed in the
endoscopy unit or even at patient’s bedside and may reduce the need for repeated admissions. Key Word(s): 1. catheter; 2. Refractory ascites; 3. Paracentesis; 4. Cirrhosi; Presenting Author: WEI-FEN XIE Additional Authors: HUI QIAN, XING DENG, ZHAO-WEI HUANG, XIN ZENG, CHUAN YIN, YUE-XIANG CHEN, XIN ZHANG, JUN-PING ZHANG Corresponding Author: WEI-FEN XIE Affiliations: the second military medical university; Department of Biochemical Pharmacology, School of Pharmacy, Second Military Medical University; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University Objective: Hepatocyte nuclear factor 1α (HNF1α) is a liver-enriched transcription factor which play a key role in hepatocyte differentiation. Our previous study revealed a significant inhibitory effect of HNF1α on hepatocellular carcinoma. Herein, we sought to investigate the role of HNF1α in hepatic fibrogenesis.