Some websites provide general information about BP measurement for non-pregnant patients, but the recommendations are similar enough to

those in pregnancy to be useful. Patients, their partners and care providers should be well educated about the HDP and relevant sites are listed. Implementation of any evidence depends on individual knowledge and beliefs, as well as institutional culture. Strong recommendations should be incorporated into clinical practice. In well-resourced settings, almost all preeclampsia-related maternal deaths involve substandard care [534]. Some recommendations may require additional effort to implement, as highlighted below. • One of the new recommendations regarding blood pressure devices is: ‘The accuracy of all BP measurement devices used in hospitals or offices should be checked regularly against a calibrated device.” PFT�� in vivo This might be something that not all Canadian hospitals and offices do on a regular basis. There are many areas in which important research is pending, such as the CHIPS

trial of antihypertensive therapy and its impact on perinatal and maternal outcomes and the TIPPS trial of heparin thromboprophylaxis to prevent recurrent placental complications (including preeclampsia). There are also many important research questions for which answers are currently unavailable. Clinicians are encouraged to participate in clinical research. If the paediatric oncology research network can enrol more than 60% of their Smad inhibitor patients in RCTs, then the maternity care community should be able to improve on the <10%

recruitment rate of women by incorporating clinical research into medical practice [535]. These recommendations have been reviewed and approved by the Hypertension Guideline, Maternal Fetal Medicine and Family Physician Advisory Committees, and Executive and Council of the Society below of Obstetricians and Gynaecologists of Canada. Dr. Magee receives salary support from the BC Women’s Hospital and Health Sciences Centre. Dr. von Dadelszen receives salary support from the Child and Family Research Institute, University of British Columbia (UBC) and the Department of Obstetrics and Gynaecology, UBC. PVD is a paid consultant of Alere International for work not related to the current manuscript. This document reflects emerging clinical and scientific advances and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Local institutions can dictate amendments to these opinions. They should be well documented if modified at the local level. This guideline was developed by the Canadian Hypertensive Disorders of Pregnancy Working Group, with support from the SOGC and the BC College of Physicians and Surgeons Library Services. “
“Placental dysfunction has long been implicated in the pathophysiology of pre-eclampsia.