The bit aspect ratio (BAR) and magnetic spacing between the write head and the medium were varied and the system with the lowest write error rate was found to be a 1:1 BAR, shingled recording
system. For single-track recording a 2:1 AZD6094 order BAR and a magnetic spacing of 3.5 nm gave the lowest write-error rate. (C) 2011 American Institute of Physics. [doi:10.1063/1.3536666]“
“In this study, capillary extrusion experiments and rupture visualization experiments were carried out with a combined die configuration where two different dies were attached in a capillary rheometer. We observed that the gross melt fracture (GMF) and rupture of the melt occurred simultaneously when the diameter of the die located at the upstream position was larger than that of the die located downstream. However, when the location of the dies were interchanged, that is, the diameter of the upstream die was smaller than that of the downstream die, the upstream rupture did not accompany GMF up to a certain extent of shear rate. From these observations, we present a new theory on the origin of GMF. (C) 2011
Wiley Periodicals, Inc. J Appl Polym Sci 121: 2812-2817, 2011″
“Background: The cholesterol-lowering effectiveness of plant sterol (PS) therapy is hindered by wide-ranging variability in LDL-cholesterol responsiveness across individuals. To capitalize on the LDL-cholesterol-lowering Navitoclax potential of PS in the clinical setting, it is paramount to characterize the metabolic factors that underlie this heterogeneity of responsiveness.
Objective: The objective was to investigate the relation between cholesterol synthesis and plasma LDL-cholesterol reductions in response to PS consumption.
Design: We evaluated previously conducted clinical PS interventions incorporating stable-isotope measures of cholesterol synthesis and conducted feeding studies in animal models of response (Syrian Golden hamsters) and nonresponse (C57BL/6J mice) to PS consumption.
Results: From our clinical study population (n = 113), we www.selleckchem.com/products/bix-01294.html identified 47 nonresponders
(3.73 +/- 1.10% change in LDL cholesterol) and 66 responders (215.16 +/- 1.04% change in LDL cholesterol) to PS therapy. The basal cholesterol fractional synthesis rate (FSR) as measured by direct deuterium incorporation was 23% higher (P = 0.003) in the nonresponder subgroup than in responders to PS therapy. The basal cholesterol FSR correlated (r = 0.22, P = 0.02) with the percentage change in LDL cholesterol after PS intervention. In support of our clinical observations, nonresponding mice showed a 77% higher (P = 0.001) basal cholesterol FSR than that of responding hamsters. Compared with control mice, PS-fed mice showed an increase in hepatic nuclear sterol regulatory element binding protein 2 abundance (1.3-fold of control, P = 0.04) and beta-hydroxy-beta-methylglutaryl coenzyme A reductase-mRNA expression (2.