Thus, this additional experiment rules out explanations of vestib

Thus, this additional experiment rules out explanations of vestibular-induced analgesia based on tactile gating of pain (Model 2), and confirms Model 1 (see Fig.

3A). This experiment further suggests that a common vestibular signal has projections to multiple independent somatic sensory systems, enhancing tactile perception and directly reducing acute pain perception. Although vestibular inputs produce no overt, recognizable conscious sensations, the vestibular system provides continuous information to the brain to maintain orientation in space (Angelaki and Cullen, 2008). A common vestibular input projects to multiple independent somatic sensory systems, directly increasing tactile perceptual processing, and directly decreasing perceptual processing of nociceptive stimuli. This finding provides new insights into the role of the vestibular Bortezomib in vivo system in buy DZNeP multisensory interactions, and in bodily awareness. Several multimodal sensory areas are known to receive both vestibular information and information from other modalities, notably vision and somatosensation (Faugier-Grimaud and Ventre,

1989). For example, functional imaging studies highlighted an anatomical overlap of vestibular and somatosensory projections in primary and secondary somatosensory cortices bilaterally (Bottini et al., 1994; Fasold et al., 2002; Emri et al., 2003). The bilateral modulations of touch and pain that we observed are consistent with this neuroimaging evidence. Our bilateral effects further suggest that the vestibular modulation of somatosensation may particularly Methamphetamine involve cortical areas whose neurons have bilateral somatosensory receptive fields, or strong transcallosal connections. The secondary somatosensory cortex is one such area (Iwamura et al., 1994). Interestingly, this area plays a major role in both

touch and pain perception (Ploner et al., 1999). A striking feature of vestibular multisensory interactions, therefore, is the specific independent modulation of distinct somatosensory submodalities. Decreases in tactile threshold demonstrate an up-regulation of tactile processing, while increases in pain threshold demonstrate a down-regulation of nociceptive processing. The pattern of correlation across participants between touch and pain effects suggests that both these modulations result from a common vestibular drive. Oculomotor and somatosensory effects of vestibular stimulation appeared to reflect a single latent factor. This view is also supported by a control experiment with nociceptive-specific laser stimulation. The vestibular system thus modulates connections with different somatosensory submodalities, regulating the activity in multiple sensory systems independently. Interestingly, human neuroimaging studies support this model, showing that vestibular stimulation both increases somatosensory cortex activations (Bottini et al., 1994, 1995; Bense et al., 2001; Fasold et al., 2002; Emri et al., 2003), but deactivates visual cortex (Bense et al., 2001).

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