However, the other clinical and histological findings, electron microscopic findings and renal survivals did not differ among the four groups. Proteinuria was independently associated with an increase in risk of doubling of creatinine (P = 0.005), however, IgG and IgM depositions
Trametinib were not by multivariate Cox regression. Conclusion: The presence of other Ig classes, besides IgA deposits, was found to be associated with glomerular obsolescence and tuft adhesions, however, without any effect on renal survival in IgAN. “
“Diabetic Kidney Disease (DKD) incidence is rising in Singapore. While measures to prevent onset and early detection of diabetes as well as optimal diabetes and blood pressure control are important, early detection and treatment of DKD at primary care are crucial to ameliorate its course. This study aimed to evaluate the prevalence of DKD in a primary care cluster in Singapore and identify its risk factors in a multi ethnic Asian population. 57,594 patients with Type 2 Diabetes Mellitus (T2DM) followed-up at the National Healthcare Group Polyclinics with eGFR and at least two urine Albumin/Creatinine Ratio (UACR) were stratified into DKD stages: Normoalbuminuria
(NA, UACR <30mg/g), Microalbuminuria (MI, UACR 30-299mg/g), Macroalbuminuria (MA, >300mg/g) and Renal Impairment (RI, eGFR <60mL/min/1·73m2). Factors associated with DKD stages were evaluated. Overall MAPK Inhibitor Library concentration DKD prevalence (T2DM with MI, MA or RI) was high at 52·5%; 32·1% had MI, 5·3% had MA and 15·1% had RI. DKD prevalence within ethnic subpopulations was different: 52·2% of Chinese, Avelestat (AZD9668) 60·4% of Malays and 45·3% of Indians had DKD respectively. Malays had a 1·42-fold higher while Indians had a 0·86-fold lower of DKD prevalence. Other independent risk factors were age, female gender, duration of diabetes and hypertension, HbA1c and BMI. The high prevalence of DKD and its interethnic differences suggest need
for additional measures to optimise the care of T2DM at primary care to mitigate its progression. “
“YAMAMOTO RYOHEI1, MARUYAMA SHOICHI2, YOKOYAMA HITOSHI3, MATSUO SEIICHI2, IMAI ENYU4 1Department of Geriatric Medicine and Nephrology, Osaka Univeristy; 2Department of Nephrology, Nagoya University Graduate School of Medicine; 3Department of Nephrology, Kanazawa Medical University Graduate School of Medicine; 4Nakayamadera Imai Clinic Introduction: Previous studies have reported persistent nephrotic-range proteinuria resistant to immunosuppressive therapy as a significant predictor of renal prognosis in primary nephrotic syndrome. However, optimal time period to diagnose resistance to immunosuppressive therapy remains unknown.