PubMed 20. Kai L, Samuel SK, Quisinostat mw Levenson AS: Resveratrol enhances p53 acetylation and apoptosis

in prostate cancer by inhibiting MTA1/NuRD complex. Int J Cancer 2010,126(7):1538–1548.PubMed 21. Li DQ, Pakala SB, Reddy SD, Ohshiro K, Peng SH, Lian Y, Fu SW, Kumar R: Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J Biol Chem 2010,285(13):10044–10052.PubMedCrossRef Authors’ contributions QS, HZ and MW KU55933 carried out the in vitro experiments. WS, MY and YF carried out the in vivo experiments. YL and YC performed statistical analysis. XZ conceived of the study, participated in its design and coordination and drafted the manuscript. Regorafenib All authors read and approved the final manuscript.”
“Introduction Cancer of the oesophagus consists of two major histological subtypes – squamous cell carcinoma and adenocarcinoma. These clinically, biologically and morphologically distinct cancers, display different epidemiology and mandate different clinical approaches to their management. Adenocarcinoma occurs in the lower third of the oesophagus

and oesophago-gastric junction and shares much in terms of phenotype with gastric cancer. Similar to gastric cancer, intestinal metaplasia can be a prominent precursor lesion in adenocarcinoma of the oesophagus [1, 2]. This condition is known as Barrett’s oesophagus. Barrett’s can represent a pre-malignant stage for oesophageal cancer and can manifest as low risk (non dysplastic) lesions or higher risk lesions

showing dysplasia histologically which can be low or high grade. Oesophageal cancer (OAC) usually presents late with symptoms such as dysphagia, weight loss, substernal pain or pressure or systemic symptoms and this is reflected by poor 5 year survival figures (less than 10% for patients with advanced disease [3]). Neuroepithelial Transforming Gene 1 (NET1) is a guanine nucleotide exchange factor (GEF) which acts via activating RhoA [4]. Rho proteins belong to the Ras superfamily of GTPases and are involved in regulating the actin cytoskeleton, signal transduction and gene transcription. These molecules bring about their downstream effects by their GTPase activity, shuttling between an inactive GDP-bound and an active GTP-bound Resminostat state. This cyclical activation/inactivation brings about a conformational change with resultant downstream effects involving a wide range of cellular processes, including cell motility [5]. Rho activation occurs in response to many cellular stimuli, including lysophosphatidic acid (LPA). LPA is a bioactive phospholipid and potent signalling molecule which acts through a family of G protein coupled receptors [6]. It induces cellular proliferation through its receptors and activation of Rho. In our previous studies LPA activation of RhoA was shown to be mediated via NET1 in gastric cancer [4]. NET1 is involved in cytoskeletal organisation and cancer cell invasion [7–10].