ROTEM® parameters: CT – clotting time; CFT – clot formation time; ∝ – alpha angle; MCF – maximum clot firmness; LY – clot lysis. WB – whole blood; Cit – citrated blood. The preference for which viscoelastic tests to use appears to reside primarily on geography, with centers in North America favouring TEG® while Europeans prefer ROTEM®. Overall, the prevalent opinion is that the two tests are equivalent with interchangeable results and interpretations. It is curious to note however, that treatment
recommendations seem to vary according to which test it is based on. Transfusion algorithms based on ROTEM® appear to frequently recommend fibrinogen [9] while TEG®-based algorithms appear to recommend plasma [7]. It is not clear whether the results from these two apparently Epigenetics inhibitor related tests are interchangeable and can be similarly interpreted. Considering the growing importance of TEG® and ROTEM® in trauma, attested by the growing number of viscoelastic test based algorithms and trauma centers adopting them as standard of care, we buy MLN4924 proposed a literature review on the topic. The goal is to appraise the evidence on the comparability between TEG® and ROTEM® as well as to perform a descriptive review of the parameters
used in each test, in the setting of adult trauma patients. Methods We performed a review of the literature searching PUBMED database using the keywords “Savolitinib supplier thromboelastography” and “comparison”,
between 2000 and 2011. Studies were eligible for inclusion if they were original and directly compared TEG® with ROTEM®. In view of the possibility that only a small number of such studies would be found, we decided to perform an additional analysis. All studies on either TEG® or ROTEM® in trauma were included and each individual test Avelestat (AZD9668) parameter was scrutinized on its role in diagnosing early coagulopathy, guiding transfusion and indicating prognosis. Then the role of similar test parameters from TEG® and ROTEM® was compared aiming to identify whether they were comparable. For this additional analysis the review used the keywords “thromboelastography” and “trauma” in the PUBMED database. Studies were excluded if they were experimental or consisted of case reports. All full-text versions of the studies were retrieved and duplicate studies were excluded. In this review (see Table 1), the viscoelastic test parameters will be referred to as r/CT, when referring to the initiation of the clotting process of both tests or as r when specifically referring to TEG® or CT when specifically referring to ROTEM®.