The LAQCA is a self-administered questionnaire. The process of development Adriamycin datasheet and validation of the questionnaire consisted of two steps. In total, 92 children/adolescents participated in the process.31 The final version of the tool uses 71 items, divided into seven parts: physical activities (20 items), work activities (4 items), outdoor activities (16 items), emotions and emotional behaviors (6 items), home care (11 items), eating and drinking (5 items), and miscellaneous (9 items). The internal consistency and reproducibility of the questionnaire were assessed with an independent sample of 46 asthmatic children.31 The visibility index of

the tool was 0.05 articles/year. A tool developed in the United States in 2005 to assess HRQoL in children with asthma, aged 5 to 12 years. The PAHOM consists of 71 items divided into seven dimensions: absence of symptoms, moderate respiratory problems, severe respiratory problems, emotional absence, presence

of emotional problems, lack of activity, and presence of activity problems. Unlike most current health outcome measures, PAHOM provides a calendar as a visual aid to help the children remember their health status during CP690550 the last seven days.32 The visibility index of the tool was 0.14 articles/year. Developed in Canada in 1996 to evaluate HRQoL of children and adolescents aged 7 to 17 years, it meets the following criteria: reflects areas of function that are important O-methylated flavonoid for children with asthma, including both emotional and physical functions, is reproducible when the clinical status is stable, and is sensitive to changes that are important to the patient.33 and 34 The tool has 23 items divided in three domains (activity limitation, symptoms, emotional function). In the activity limitation domain, three of the items are ‘individualized’. At the first visit, the patient

is asked to identify three physical activities or sports he/she practices and considers important; these activities are maintained individualized for each patient throughout the follow-up. Currently, the activities are standardized: 1) physical activity, 2) activities with animals, 3) activities with friends and family. Construct validity, reproducibility, and sensitivity to change were evaluated; minimal important difference was estimated at 0.5 points.33 and 34 The visibility index of the tool was 3.56 articles/year. A generic tool developed in the U.S. in 1987, designed to measure health-related quality of life in children and adolescents aged 2 to 18 years. It has 23 items divided into five domains: physical functional status, emotional functional status, social functional status, and school functional status. The fifth domain is the psychosocial, consisting of the sum of the domains, except for the physical.