There is ample evidence that treatments that typically produce amnesia become innocuous when animals are submitted to a procedure of enhanced training. We now report that extinction of inhibitory avoidance (IA), trained with relatively low foot-shock
intensities, induces pruning of dendritic spines along the length of the apical dendrites of hippocampal CA1 neurons. When animals are trained with a relatively high foot-shock there is a high resistance to extinction, and pruning in NU7441 manufacturer the proximal and medial segments of the apical dendrite are seen, while spine count in the distal dendrite remains normal. These results indicate that pruning is involved in behavioral extinction, while maintenance of spines is a probable mechanism that mediates the protecting effect against amnesic treatments produced by enhanced training.”
“Purpose: see more To investigate the electro-reduction behaviour and determination of ciprofloxacin using a hanging mercury drop electrode.
Methods: Cyclic voltammograms of ciprofloxacin recorded in Britton -Robinson buffers pH 2 – 5 exhibit a single irreversible cathodic peak. The dependence of the peak current and peak potential values on buffer (nature, pH and concentration) and
accumulation conditions (time and potential) were examined and used for the quantitative analysis of ciprofloxacin in dosage forms and urine. Acetate buffer (0.08 M, pH 3.6) was selected as a supporting electrolyte for quantitative purposes by differential pulse and square wave adsorptive cathodic stripping voltammetry.
Results:
A reduction wave was seen in the range of -1.3 to -1.5 V. These techniques were successfully validated as per ICH guidelines and comparable to US Pharmacopoeia HPLC method. The techniques was applied to the determination of ciprofloxacin in pharmaceutical formulations (i. e. precision (RSD < 1%) and accuracy (99 -101%)), and was further extended to determine ciprofloxacin in spiked human urine with no matrix effect (i. e. LLOQ 0.01 mu g/ml, precision (RSD < 15%) and accuracy (85 -115%)).
Conclusion: Validated adsorptive cathodic stripping voltammetric technique can be recommended selleck chemicals llc for use in quality control and pharmacokinetics studies.”
“Stiff-person syndrome is a rare disorder characterized by rigidity of axial or limb muscles with episodes of co-contraction of agonist and antagonist muscles during the spasms. In some patients axial or limb involvement may predominate and may have unusual manifestations.
Case report.
Tertiary care teaching hospital.
A 42-year-old farmer presented with seasonal occurrence of hiccup and vomiting during summer months for the last 3 years. He had painful lower limb spasms lasting for 2-3 minutes every 10-15 minutes for the past 20 days.