We also examined correlates of withdrawal use using a logit model.

RESULTS: During the study period, 31.0% of females in our cohort used withdrawal. Of withdrawal users, 21.4% experienced an unintended

pregnancy compared with 13.2% of females who used only other contraceptive methods (adjusted hazard ratio 1.75, 95% confidence interval [CI] 1.23-2.49). Withdrawal users were also 7.5% more likely to have used emergency contraception selleck kinase inhibitor (adjusted odds ratio [OR] 1.57, 95% CI 1.13-2.20). Married females were 14.8% less likely than single females to use withdrawal (adjusted OR 0.58, 95% CI 0.35-0.96).

CONCLUSION: Use of withdrawal as contraception is common and might place females at higher risk of unintended pregnancy. Health care providers should be aware that many patients may use withdrawal, should consider the need for emergency contraception among these females, and should encourage them to use more effective methods of contraception.”
“This article focuses on items to consider when selecting outcome measures for a clinical study.

The choice of outcome measures depends largely on the research question and the study CT99021 chemical structure design. Sample-size requirements can vary greatly, depending on the type and the number of outcome measures selected. In this paper, we review the differences between categorical and continuous outcomes as well as the differences between primary and secondary outcomes and we discuss the concept of minimally important differences and

the problems associated with composite outcomes. We also provide instruction on how to conduct and present a sample-size calculation.”
“In the last decades significant advances have been made in successful cryopreservation of mammalian oocytes. Human P5091 research buy oocyte cryopreservation has practical application in preserving fertility for individuals at risk of compromised egg quality due to cancer treatments or advanced maternal age. While oocyte cryopreservation success has increased over time, there is still room for improvement. Oocytes are susceptible to cryodamage; which collectively entails cellular damage caused by mechanical, chemical or thermal forces during the vitrification and warming process. This review will delineate many of the oocyte intracellular and extracellular structures that are/may be stressed and/or compromised during cryopreservation. This will be followed by a discussion of the theoretical basis of oocyte vitrification and warming, and a non-exhaustive review of current experimental data and clinical expectations of oocyte vitrification will be presented. Finally, a forward-thinking vision of a potential means of modifying and improving vitrification and warming procedures and success will be proposed.